Isabella I (Spanish: Isabel, 22 April 1451 – 26 November 1504) reigned as Queen of Castile from 1474 until her death. Her marriage to Ferdinand II of Aragon became the basis for the political unification of Spain under their grandson, Charles I. After a struggle to claim her right to the throne, she reorganized the governmental system, brought the crime rate to the lowest it had been in years, and unburdened the kingdom of the enormous debt her brother had left behind. Her reforms and those she made with her husband had an influence that extended well beyond the borders of their united kingdoms. Isabella and Ferdinand are known for completing the Reconquista, ordering conversion or exile of their Muslim and Jewish subjects, and for supporting and financing Christopher Columbus's 1492 voyage that led to the opening of the New World and to the establishment of Spain as the first global power which dominated Europe and much of the world for more than a century. Isabella, granted together with her husband the title "the Catholic" by Pope Alexander VI, was recognized as a Servant of God by the Catholic Church in 1974. A Spanish TV series was made in her honor. The show was broadcast by the Spanish Television Channel La 1 from 2012 to 2014.

Vladimir Ilyich Ulyanov, better known by the alias Lenin (/ˈlɛnɪn/; 22 April 1870 – 21 January 1924), was a Russian communist revolutionary, politician and political theorist. He served as head of government of Soviet Russia from 1917 to 1924 and of the Soviet Union from 1922 to 1924. Under his administration, Russia and then the wider Soviet Union became a one-party communist state governed by the Russian Communist Party. Ideologically a Marxist, he developed political theories known as Leninism.

Glen Travis Campbell (April 22, 1936 – August 8, 2017) was an American singer, guitarist, songwriter, television host, and actor. He was best known for a series of hit songs in the 1960s and 1970s, and for hosting a music and comedy variety show called The Glen Campbell Goodtime Hour on CBS television, from January 1969 through June 1972. He released over 70 albums in a career that spanned five decades, accumulating over 45 million record sales worldwide, including 12 gold albums, four platinum albums, and one double-platinum album.

John Joseph "Jack" Nicholson (born April 22, 1937) is an American actor and filmmaker who has performed for more than 60 years. Nicholson is known for playing a wide range of starring or supporting roles, including satirical comedy, romance and dark portrayals of antiheroes and psychopathic characters. In many of his films, he has played the "eternal outsider, the sardonic drifter"; someone who rebels against the social structure.

James Stephen "Steve" Fossett (April 22, 1944 – c. September 3, 2007) was an American businessman and a record-setting aviator, sailor, and adventurer. He was the first person to fly solo nonstop around the world in a balloon. He made his fortune in the financial services industry and was best known for many world records, including five nonstop circumnavigations of the Earth: as a long-distance solo balloonist, as a sailor, and as a solo flight fixed-wing aircraft pilot.

Peter Kenneth Frampton (born 22 April 1950) is a British-American rock musician, singer, songwriter, producer, and guitarist. He was previously associated with the bands Humble Pie and The Herd. At the end of his 'group' career was Frampton's international breakthrough album, his live release Frampton Comes Alive!. The album sold more than 8 million copies in the United States and spawned several hit singles. Since then he has released several major albums. He has also worked with David Bowie and both Matt Cameron and Mike McCready from Pearl Jam, among others.

Jeffrey Dean Morgan (born April 22, 1966) is an American actor. He is known for his roles as John Winchester on the fantasy horror series Supernatural (2005–07), Denny Duquette on the medical drama series Grey's Anatomy (2006–09), The Comedian in the superhero film Watchmen (2009), Jason Crouse on the political drama series The Good Wife (2015–16), Negan on the horror drama series The Walking Dead (2016–present), and Harvey Russell in Rampage (2018).

Amber Laura Heard (born April 22, 1986) is an American actress. She made her film debut in 2004 in the sports drama Friday Night Lights. After small roles in North Country and Alpha Dog, Heard played her first leading role in All the Boys Love Mandy Lane (2006) and appeared in The CW television show Hidden Palms (2007).