Isabella I (Spanish: Isabel, 22 April 1451 – 26 November 1504) reigned as Queen of Castile from 1474 until her death. Her marriage to Ferdinand II in 1469 became the basis for the de facto unification of Spain. After a struggle to claim her right to the throne, she reorganized the governmental system, brought the crime rate to the lowest it had been in years, and unburdened the kingdom of the enormous debt her brother had left behind. Her reforms and those she made with her husband had an influence that extended well beyond the borders of their united kingdoms. Isabella and Ferdinand are known for completing the Reconquista, ordering conversion or exile of their Muslim and Jewish subjects, and for supporting and financing Christopher Columbus's 1492 voyage that led to the opening of the New World and to the establishment of Spain as the first global power which dominated Europe and much of the world for more than a century. Isabella, granted together with her husband the title "the Catholic" by Pope Alexander VI, was recognized as a Servant of God by the Catholic Church in 1974.

Vladimir Ilyich Ulyanov (22 April 1870 – 21 January 1924), better known by his alias Lenin, was a Russian revolutionary, politician, and political theorist. He served as head of government of Soviet Russia from 1917 to 1924 and of the Soviet Union from 1922 to 1924. Under his administration, Russia and then the wider Soviet Union became a one-party communist state governed by the Russian Communist Party. Ideologically a communist, he developed a variant of Marxism known as Leninism; his ideas were posthumously codified as Marxism–Leninism.

Glen Travis Campbell (April 22, 1936 – August 8, 2017) was an American singer, guitarist, songwriter, television host, and actor. He was best known for a series of hit songs in the 1960s and 1970s, and for hosting a music and comedy variety show called The Glen Campbell Goodtime Hour on CBS television, from January 1969 until June 1972. He released over 70 albums in a career that spanned five decades, selling over 45 million records worldwide, including twelve gold albums, four platinum albums, and one double-platinum album.

John Joseph Nicholson (born April 22, 1937) is an American actor and filmmaker. He is known for playing a wide range of starring or supporting roles, including comedy, romance, and darkly comic portrayals of anti-heroes and villainous characters. In many of his films, he played the "eternal outsider, the sardonic drifter", someone who rebels against the social structure.

James Stephen "Steve" Fossett (April 22, 1944 – September 3, 2007) was an American businessman and a record-setting aviator, sailor, and adventurer. He was the first person to fly solo nonstop around the world in a balloon and in a fixed-wing aircraft. He made his fortune in the financial services industry and was best known for many world records, including five nonstop circumnavigations of the Earth: as a long-distance solo balloonist, as a sailor, and as a solo flight fixed-wing aircraft pilot.

Peter Kenneth Frampton (born 22 April 1950) is an English rock musician, singer, songwriter, producer, and guitarist. He was previously associated with the bands Humble Pie and the Herd. After the end of his 'group' career, as a solo artist, Frampton released several albums including his international breakthrough album, the live release Frampton Comes Alive!. The album sold more than 8 million copies in the United States and spawned several hit singles. Since then he has released several other albums. He has also worked with Ringo Starr, David Bowie and both Matt Cameron and Mike McCready from Pearl Jam, among others.

Jeffrey Dean Morgan (born April 22, 1966) is an American actor of film and television. He is known for his roles as John Winchester in the fantasy horror series Supernatural (2005–2007; 2019), Denny Duquette in the medical drama series Grey's Anatomy (2006–2009), the Comedian in the superhero film Watchmen (2009), Jason Crouse in the political drama series The Good Wife (2015–2016), Negan in the horror drama series The Walking Dead (2016–present), and Harvey Russell in Rampage (2018).

Amber Laura Heard (born April 22, 1986) is an American actress and model. Born and raised in Texas, she made her film debut in a minor supporting role in the sports drama Friday Night Lights (2004), followed by a series of other small roles in television and film. Her first leading role was in the horror film All the Boys Love Mandy Lane (2006), but it was not released in the United States until 2013 due to distribution problems. Her second major role came in the short-running The CW television series Hidden Palms (2007).